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Mir-708 microRNA precursor family : ウィキペディア英語版 | Mir-708 microRNA precursor family In molecular biology mir-708 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-708 is located on chromosome 11q14.1 and is endcoded in intron 1 of the ''ODZ4'' gene.〔 〕 It is most highly expressed in the brain and eyes, and has a supposed role in endoplamic reticular stress of the eye.〔 〕 ==Ewing's Sarcoma== miR-708 has been implicated in the bone-specific Ewing's sarcoma. Upregulation of the DNA repair protein EYA3 in this tumour is mediated by the fusion protein transcription factor EWS/FLI1, which in turn is via repression of miR-708.〔 〕 miR-708 targets the 3'UTR of EYA3, rather than binding directly to its promoter region. High levels of EYA3 in Ewing's sarcoma are accordingly correlated with low levels of miR-708.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Mir-708 microRNA precursor family」の詳細全文を読む
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